an:05727546
Zbl 1189.92007
Magin, Richard L.
Fractional calculus models of complex dynamics in biological tissues
EN
Comput. Math. Appl. 59, No. 5, 1586-1593 (2010).
00259795
2010
j
92C05 92C37 92C30 26A33 28A80
impedance; viscosity; stress
Summary: Fractional (non-integer order) calculus can provide a concise model for the description of the dynamic events that occur in biological tissues. Such a description is important for gaining an understanding of the underlying multiscale processes that occur when, for example, tissues are electrically stimulated or mechanically stressed. The mathematics of fractional calculus has been applied successfully in physics, chemistry, and material sciences to describe dielectrics, electrodes and viscoelastic materials over extended ranges of time and frequency. In heat and mass transfer, for example, the half-order fractional integral is the natural mathematical connection between thermal or material gradients and the diffusion of heat or ions. Since the material properties of tissues arise from the nanoscale and microscale architecture of subcellular, cellular, and extracellular networks, the challenge for bioengineers is to develop new dynamic models that predict macroscale behavior from microscale observations and measurements. We describe three areas of bioengineering research (bioelectrodes, biomechanics, bioimaging) where fractional calculus is being applied to build these new mathematical models.