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Computer control of cell mass concentration in continuous culture. (English) Zbl 0686.92024
Summary: The performances of three types of cell mass control algorithms were tested experimentally in a continuously stirred tank biological reactor (CSTBR). While the performance of the PID controller was undesirable and parameter tuning was not easy, the extended least-squares self-tuning regulator (ELS-STR) and a bilinear model adaptive controller (BMAC) indicated excellent performances. Especially, the BMAC, based on a nonlinear predictor model with only one parameter to be identified, showed less excessive fluctuation of control action and better adaptation performance over the ELS-STR.
92F05 Other natural sciences (mathematical treatment)
92Cxx Physiological, cellular and medical topics
92-08 Computational methods for problems pertaining to biology
93C55 Discrete-time control/observation systems
Full Text: DOI
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