×

zbMATH — the first resource for mathematics

Computer control of cell mass concentration in continuous culture. (English) Zbl 0686.92024
Summary: The performances of three types of cell mass control algorithms were tested experimentally in a continuously stirred tank biological reactor (CSTBR). While the performance of the PID controller was undesirable and parameter tuning was not easy, the extended least-squares self-tuning regulator (ELS-STR) and a bilinear model adaptive controller (BMAC) indicated excellent performances. Especially, the BMAC, based on a nonlinear predictor model with only one parameter to be identified, showed less excessive fluctuation of control action and better adaptation performance over the ELS-STR.
MSC:
92F05 Other natural sciences (mathematical treatment)
92Cxx Physiological, cellular and medical topics
92-08 Computational methods for problems pertaining to biology
93C55 Discrete-time control/observation systems
PDF BibTeX XML Cite
Full Text: DOI
References:
[1] Chen, L.H.; Chang, L.C., Global stabilization of a biological reactor by linear feedback control, Chem. engng commun., 27, 231, (1984)
[2] DiBasio, D.; Lim, H.C.; Weigand, W.A., An experimental investigation of stability and multiplicity of steady states in a biological reactor, A.I.ch.E. jl, 27, 2, (1981)
[3] DiBasio, D.; Lim, H.C.; Weigand, W.A., Constrained control of an unstable biological reactor, A.I.ch.E. jl, 30, 520, (1984)
[4] DiBasio, D.; Lim, H.C.; Weigand, W.A.; Tsao, G.T., Phase plane analysis of feedback control of unstable steady states in a biological reactor, A.I.ch.E. jl, 24, 686, (1978)
[5] Franco, C.M.M.; Smith, J.E.; Berry, D.R., Changes in intermediate levels during batch culture of S. cerevisiae, Biotech. lett., 6, 803, (1984)
[6] Furuhawa, K.; Heinzle, E., Influence of oxygen on the growth of S. cerevisiae in continuous culture, Biotech. bioengng, 25, 2293, (1983)
[7] Goodwin, G.C.; Sin, K.S., ()
[8] Karim, M.N.; Linden, J.; Lee, G.K.F., Adaptive control of a continuous fermentation system, ()
[9] Karim, M.N.; Morura, A.R.; Grogan, A., Modeling and adaptive control of a fermentation system, (), 45
[10] Lee, C.; Lim, H., New device for continuously monitoring the optical density of concentrated microbial cultures, Biotech. bioengng, 12, 639, (1980)
[11] Mateles, R.I.; Ryu, D.Y.; Yasuda, T., Measurement of unsteady state growth rates of micro-organisms, Nature, 16, 263, (1965)
[12] Ziegler, J.G.; Nichols, N.B., Optimum settings for automatic controllers, Trans. ASME, 64, 759, (1942)
This reference list is based on information provided by the publisher or from digital mathematics libraries. Its items are heuristically matched to zbMATH identifiers and may contain data conversion errors. It attempts to reflect the references listed in the original paper as accurately as possible without claiming the completeness or perfect precision of the matching.