Computer control of cell mass concentration in continuous culture.

*(English)*Zbl 0686.92024Summary: The performances of three types of cell mass control algorithms were tested experimentally in a continuously stirred tank biological reactor (CSTBR). While the performance of the PID controller was undesirable and parameter tuning was not easy, the extended least-squares self-tuning regulator (ELS-STR) and a bilinear model adaptive controller (BMAC) indicated excellent performances. Especially, the BMAC, based on a nonlinear predictor model with only one parameter to be identified, showed less excessive fluctuation of control action and better adaptation performance over the ELS-STR.

##### MSC:

92F05 | Other natural sciences (mathematical treatment) |

92Cxx | Physiological, cellular and medical topics |

92-08 | Computational methods for problems pertaining to biology |

93C55 | Discrete-time control/observation systems |

##### Keywords:

microbial metabolism; cell mass control algorithms; continuously stirred tank biological reactor; extended least-squares self-tuning regulator; bilinear model adaptive controller; nonlinear predictor model
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##### References:

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