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A note on tests for interaction in quantal response data. (English) Zbl 1052.62047
Summary: There are few distribution-free methods for detecting interaction in fixed-dose trials involving quantal response data, despite the fact that such trials are common. We present three new tests to address this issue, including a simple bootstrap procedure. We examine the power of the likelihood ratio test and our new bootstrap test statistic using an innovative linear extrapolation power-estimation technique described by D. D. Boos and J. Zhang [J. Am. Stat. Assoc. 95, 486–492 (2000)].
MSC:
62G10 Nonparametric hypothesis testing
62G09 Nonparametric statistical resampling methods
62P10 Applications of statistics to biology and medical sciences; meta analysis
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