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Transmission potential of the novel avian influenza A(H7N9) infection in mainland China. (English) Zbl 1412.92303
Summary: We propose and analyze a mathematical model to mimic its transmission dynamics to assess the transmission potential of the novel avian influenza A(H7N9) virus. By fitting the model to data of the confirmed human cases we estimate the reproduction number for human-to-human transmission as 0.467 (95% CI 0.387–0.651). Simulation results indicate that approximate twofold of the current human-to-human transmission rate or periodic outbreaks of avian influenza in poultry may induce an outbreak in human. Through the recent limited transmission potential of the novel avian influenza A(H7N9) virus, a new outbreak may be possible due to virus mutation and adaption or periodic outbreaks in poultry, and hence careful surveillance and persistent intervention strategies in poultry have to be required.

MSC:
92D30 Epidemiology
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[1] CDC. CDC Health Advisory: Human Infections with Novel Influenza A (H7N9) Viruses, US Department of Health and Human Services, CDC, Health Alert Network, Atlanta, GA, 2013. Available at 〈http://emergency.cdc.gov/han/han00344.asp〉.
[2] Chen, Y., Liang, W.F., Yang, S.G., et al., 2013. Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome. Lancet. 381 (9881) 1916-1925,. http://dx.doi.org/10.1016/S0140-6736(13)60903-4.
[3] Chinese Center for Disease Control and Prevention (China CDC): Statistics of H7N9 Confirmed Cases Beijing, China CDC, China, 2013.
[4] Chowell, G., Simonsen, L., Towers, S., Miller, M.A., Viboud, C., 2013. Transmission potential of influenza A/H7N9, February-May 2013, China. BMC Med. 11, 214.
[5] Cowling, B.J., Freeman, G., Wong, J.Y., Wu, P., et al., 2013. Preliminary inferences on the age-specific seriousness of human disease caused by avian influenza A(H7N9) infections in China, March-April 2013, Euro Surveill. 18(19). pii=20475.
[6] Diekmann, O.; Heesterbeek, J. A.P., Mathematical epidemiology of infectious diseasesmodel building, analysis and interpretation, (2000), John Wiley & Son, Ltd. Chichester · Zbl 0997.92505
[7] Geweke, J., Evaluating the accuracy of sampling-based approaches to the calculation of posterior moments, (Bernardo, J. M.; Berger, J.; Dawid, A. P.; Smith, A. F.M., Bayesian Statistics, vol. 4, (1992), Oxford University Press Oxford), 169-193
[8] Haario, H.; Laine, M.; Mira, A.; Saksman, E., Dram: efficient adaptive MCMC, Stat. Comput., 16, 339-354, (2006)
[9] Hatchett, R. J.; Mecher, C. E.; Lipsitch, M., Public health interventions and epidemic intensity during the 1918 influenza pandemic, Proc. Natl. Acad. Sci. USA, 104, 7582-7587, (2007)
[10] Horby, P., April 25, 2013. H7N9 is a virus worth worrying about. Nature 496 (7446), 399. http://dx.doi.org/10.1038/496399a.
[11] Li, Q., Zhou, L., Zhou, M., et al., April 24, 2013. Preliminary report: epidemiology of the avian influenza A (H7N9) outbreak in China. N. Engl. J. Med. http//:dx.doi.org.10.1056/NEJMoa1304617.
[12] Ministry of Agriculture of the Peoples Republic of China. No H7N9 Virus Found In Poultry Farm Samples, Ministry of Agriculture, Beijing, China, 2013. Available at http://english.agri.gov.cn/news/ dqnf/201304/t20130427-19537.htm.
[13] Nishiura, H.; Mizumoto, K.; Ejima, K., How to interpret the transmissibility of novel influenza A(H7N9): an analysis of initial epidemiological data of human cases from China, Theor. Biol. Med. Model., (2013)
[14] The 110 Confirmed Cases of Human Infection with H7N9, January 1st-28th, 2014, Mainland China. 〈http://js.people.com.cn/html/2014/01/31/285833.html〉(In Chinese).
[15] Tang, S. Y.; Xiao, Y. N.; Yang, Y. P., Community-based measures for mitigating the 2009 H1N1 pandemic in China, PLoS ONE, 5, 1-1, (2010), (e10911)
[16] Towers, S.; Feng, Z., Pandemic H1N1 influenza: predicting the course of a pandemic and assessing the efficacy of the planned vaccination programme in the united states, Euro Surveill., 14, 41, (2009), (pii=19358)
[17] World Health Organization. Global Alert and Response (GAR): Human Infection with Influenza A(H7N9) Virus in China, World Health Organization, Geneva, Switzerland, 2013. Available at 〈http://www.who.int/csr/don/2013-04-01/en/index.html〉.
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