×

zbMATH — the first resource for mathematics

On the sexual transmission dynamics of hepatitis B virus in China. (English) Zbl 1406.92650
Summary: In a previous study we noticed that there might be co-infections of HBV and HIV by comparing incidence rates of these two diseases in China. The comparisons between the incidence data of HBV and sexually transmitted diseases (including AIDS, HIV, syphilis and gonorrhea) in China demonstrate that sexual transmission is an important route of spread of HBV in China. On the basis of this fact, in this paper we propose a compartmental model including under-aged children, male adults, and female adults. The effect of sexual transmission on the spread and prevalence of HBV in China is studied. The model is employed to simulate the HBV incidence data reported by the Chinese Center for Disease Control and Prevention for under-aged children, adult males, and adult females, respectively. The sensitivity analysis of the basic reproduction number indicates that it is important and crucial to increase the immunization rate for both under-aged children and adults in order to control the transmission of HBV in China. Our study suggests that effective control measures for hepatitis B in China include enhancing public education and awareness about hepatitis B virus, particularly about the fact that hepatitis B is a sexually transmitted disease, and increasing the immunization rate for both under-aged children and adults, especially for those groups of high risk.

MSC:
92D30 Epidemiology
PDF BibTeX XML Cite
Full Text: DOI
References:
[1] Alter, M. J.; Ahtore, J.; Weisfuse, I.; Starko, K.; Vacalis, T. D.; Maynard, J. E., Hepatitis B virus transmission between heterosexuals, J. Am. Med. Assoc., 256, 1307-1310, (1986)
[2] Alter, M. J.; Coleman, P. J.; Alexander, W. J.; Kramer, E.; Miller, J. K.; Mandel, E.; Hadler, S. C.; Margolis, H. S., Importance of heterosexual activity in the transmission of hepatitis B and non-A, non-B hepatitis, J. Am. Med. Assoc., 262, 1201-1205, (1989)
[3] Chinese Center for Disease Control and Prevention, 2004-2012. Reports on Infectious Diseases 〈http://www.chinacdc.cn/tjsj/fdcrbbg/〉.
[4] Chee, G., Xie, Z., Nakhimovsky, S., 2012. Evaluation of GAVI-Government of China hepatitis B vaccination program. The GAVI (The Global Alliance for Vaccines and Immunization) Alliance 〈http://www.gavialliance.org/results/evaluations/evaluation-of-the-gavi-government-of-china-hepatitis-b-vaccination-programme/〉.
[5] Cui, F.; Wang, X.; Cao, L., Progress in hepatitis B prevention through universal infant immunization-China, 1997-2006, Morb. Mortal. Wkly. Rep., 56, 18, 441-445, (2007)
[6] Diekmann, O.; Heesterbeek, J. A.P.; Roberts, M. G., The construction of nextgeneration matrices for compartmental epidemic models, J. R. Soc. Interface, 7, 873-885, (2010)
[7] Edmunds, W. J.; Medley, G. F.; Nokes, D. J., The influence of age on the development of the hepatitis B carrier state, Proc. R. Soc. Lond. B, 253, 197-201, (1993)
[8] Edmunds, W. J.; Medley, G. F.; Nokes, D. J., The transmission dynamics and control of hepatitis B virus in the gambia, Stat. Med., 15, 2215-2233, (1996)
[9] Jia, J. D.; Zhuang, H., The overview of the seminar on chronic hepatitis B, Chin. J. Hepatol., 12, 698-699, (2004)
[10] Ko, Y.; Yen, Y.; Yeh, S.; Lan, S., Female to male transmission of hepatitis B virus between Chinese spouses, J. Med. Virol., 27, 142-144, (1989)
[11] Liang, X.; Bi, S.; Yang, W., Epidemiological serosurvey of hepatitis B in China - declining HBV prevalence due to hepatitis B vaccination, Vaccine, 27, 47, 6550-6557, (2009)
[12] Liang, X.; Cui, F.; Hadler, S.; Wang, X.; Luo, H.; Chen, Y.; Kane, M.; Shapiro, C.; Yang, W.; Wang, Y., Origins, design and implementation of the China GAVI project, Vaccine, 31S, J8-J14, (2013)
[13] Liu, G. T., Comments on the prevention and research of chronic hepatitis in China, Natl. Med. J. China, 82, 74-76, (2002)
[14] London, W. T.; Drew, J. S., Sex differences in response to hepatitis B infection among patients receiving chronic dialysis treatment, Proc. Natl. Acad. Sci. U.S.A., 74, 6, 2561-2563, (1977)
[15] McLean, A. R.; Blumberg, B. S., Modelling the impact of mass vaccination against hepatitis B. I. model formulation and parameter estimation, Proc. R. Soc. Lond. B, 256, 7-15, (1994)
[16] National Health and Family Planning Commission of the People׳s Republic of China. Questions and Answers for Vaccination of Hepatitis B 〈http://www.chinacdc.cn/zxdt/201312/t20131230_92034.htm〉.
[17] National Health and Family Planning Commission of the People׳s Republic of China, 2006-2010. National Hepatitis B Virus Prevention and Control Plan 〈http://www.moh.gov.cn/mohbgt/pw10603/200804/27587.shtml〉.
[18] National Health and Family Planning Commission of the People׳s Republic of China, 2012. China Health Statistical Yearbook 〈http://www.nhfpc.gov.cn/htmlfiles/zwgkzt/ptjnj/year2012/index2012.html〉.
[19] People׳s Daily Oversea Edition, 2013. The number of hepatitis B infections had been reduced by more than 20 millions in 20 years, July 29 〈http://paper.people.com.cn/rmrbhwb/html/2013-07/29/content_1275053.htm〉.
[20] Public Health Science Data (Gonggong Weisheng Kexue Shuju Zhongxin), 2004-2012. Infectious diseases data 〈http://www.phsciencedata.cn/Share/index.jsp〉.
[21] Struve, J.; Giesecke, J.; Lindh, G.; Weiland, O., Heterosexual contact as a major route for transmission of acute hepatitis B among adults, J. Infect., 20, 111-121, (1990)
[22] Sun, Z. T.; Ming, L. H.; Zhu, X.; Lu, J. H., Prevention and control of hepatitis B in China, J. Med. Virol., 67, 447-450, (2002)
[23] The Central People׳s Government of the People׳s Republic of China. 2009. Guidelines on Deepening the Reform of Health-care System (2009-2011), April 7 〈http://www.gov.cn/zwgk/2009-04/07/content_1279256.htm〉.
[24] van den Driessche, P.; Watmough, J., Reproduction numbers and sub-threshold endemic equilibria for compartmental models of disease transmission, Math. Biosci., 180, 29-48, (2002) · Zbl 1015.92036
[25] Williams, J. R.; Nokes, D. J.; Medley, G. F.; Anderson, R. M., The transmission dynamics of hepatitis B in the uka mathematical model for evaluating costs and effectiveness of immunization programmes, Epidemiol. Infect., 116, 71-89, (1996)
[26] World Health Organization, 2002. Hepatitis B, WHO/CDS/CSR/LYO/2002.2:Hepatitis B. World Health Organization.
[27] World Health Organization, 2014. Hepatitis B. Fact sheet No. 204. Updated June 2014 〈http://www.who.int/mediacentre/factsheets/fs204/en/index.html〉.
[28] Zhao, S.-J.; Xu, Z.-Y.; Lu, Y., A mathematical model of hepatitis B virus transmission and its application for vaccination strategy in China, Int. J. Epidemiol., 29, 744-752, (2000)
[29] Zhu, D.; Guo, N.; Wang, J., Analysis of the behavior and willingness to take hepatitis B vaccine among adults in rural China, Chin. J. Health Stat., 30, 203-205, (2013)
[30] Zou, L.; Ruan, S.; Zhang, W., An age-structured model for the transmission dynamics of hepatitis B, SIAM J. Appl. Math., 70, 3121-3139, (2010) · Zbl 1210.35269
[31] Zou, L.; Zhang, W.; Ruan, S., Modelling the transmission dynamics and control of hepatitis B virus in China, J. Theor. Biol., 262, 330-338, (2010), Erratum 317 (2013) 425-427 · Zbl 1403.92316
This reference list is based on information provided by the publisher or from digital mathematics libraries. Its items are heuristically matched to zbMATH identifiers and may contain data conversion errors. It attempts to reflect the references listed in the original paper as accurately as possible without claiming the completeness or perfect precision of the matching.