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A dendritic cable model for the amplification of synaptic potentials by an ensemble average of persistent sodium channels. (English) Zbl 0978.92005
Summary: The persistent sodium current density \((I_{\text{NaP} }\)) at the soma measured with the ‘whole-cell’ patch-clamp recording method is linearized about the resting state and used as a current source along the dendritic cable (depicting the spatial distribution of voltage-dependent persistent sodium ionic channels). This procedure allows time-dependent analytical solutions to be obtained for the membrane depolarization. Computer simulated response to a dendritic current injection in the form of synaptically-induced voltage change located at a distance from the recording site in a cable with unequally distributed persistent sodium ion channel densities per unit length of cable (the so-called ‘hot-spots’) is used to obtain conclusions on the density and distribution of persistent sodium ion channels.
It is shown that the excitatory postsynaptic potentials (EPSPs) are amplified if hot-spots of persistent sodium ion channels are spatially distributed along the dendritic cable, with the local density of \(I_{\text{NaP}}\) with respect to the recording site shown to specifically increase the peak amplitude of the EPSP for a proximally placed synaptic input, while the spatial distribution of \(I_{\text{NaP}}\) serves to broaden the time course of the amplified EPSP. However, in the case of a distally positioned synaptic input, both local and nonlocal densities yield an approximately identical enhancement of EPSPs in contradiction to the computer simulations performed by R. Lipowsky et al. [J Neurophysiol. 76, 2181ff (1996)].
The results indicate that persistent sodium channels produce EPSP amplification even when their distribution is relatively sparse (i.e., approximately \(1-2\%\) of the transient sodium channels are found in dendrites of CA1 hippocampal pyramidal neurons). This gives a strong impetus for the use of the theory as a novel approach in the investigation of synaptic integration of signals in active dendrites represented as ionic cables.

MSC:
92C20 Neural biology
92C05 Biophysics
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