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Computational molecular biology. An algorithmic approach. (English) Zbl 0972.92011
A Bradford Book. Cambridge, MA: MIT Press. xviii, 314 p. (2000).
This book gives an introduction to Computational Molecular Biology, from an algorithmic point of view. It is directed at computer scientists and mathematics graduate students but will also be interesting for biologists with some background in discrete mathematics. Every chapter presents algorithmic ideas in computational biology and discusses how they are connected to molecular biology. Selected problems are considered in detail with proofs given for the results. Clearly, the book covers not all aspects of computational molecular biology but concentrates on:
(1) Computational gene hunting; (2) Restriction mapping; (3) Map assembly; (4) Sequencing; (5) DNA arrays; (6) Sequence comparisons; (7) Multiple alignments; (8) Finding signals in DNA; (9) Gene prediction; (10) Genome rearrangements; (11) Computational proteomics; (12) Problems; (13) Facts about molecular biology.
The book is well written and interesting to read. The only criticism is that more information about biological backgrounds would sometimes be helpful and several figures are distorted and should be resized.

MSC:
92C40 Biochemistry, molecular biology
92-01 Introductory exposition (textbooks, tutorial papers, etc.) pertaining to biology
68U99 Computing methodologies and applications
92-08 Computational methods for problems pertaining to biology
92D20 Protein sequences, DNA sequences
68R10 Graph theory (including graph drawing) in computer science
05C90 Applications of graph theory
68W99 Algorithms in computer science
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