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Bayesian methods in practice: Experiences in the pharmaceutical industry. (English) Zbl 0635.62106

This is an important, interesting and useful paper. Four typical applications of Bayesian methods in pharmaceutical research are outlined. The authors consider:
1. LD 50 experiments and the special problems which arise first from trend towards small experiments, and secondly from proposed changes in the form of reporting the analysis of such experiments.
2. The controversy over the use of cross-over designs - currently very widely employed - in situations where there may be carryover effects.
3. The problem of the efficient use of the data and experimental resources in the area of bioequivalence assessment, and
4. The analysis of the “nonlinear random effects models”, which underlie population pharmacokinetics and pharmacodynamic studies.
Reviewer: J.Kaufmann

MSC:

62P10 Applications of statistics to biology and medical sciences; meta analysis
62F15 Bayesian inference
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