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A stochastic model for the origin and treatment of tumors containing drug-resistant cells. (English) Zbl 0613.92006
A stochastic model for the chemotherapy of experimental tumors is presented. The focus of this model is on the presence of drug-resistant mutants and their influence on eventual treatment outcome. Equations are derived for the joint probability-generating function for the number of chemo-sensitive and chemo-resistant cells. The model is extended to two drugs and it is shown how the model may be used to make deductions regarding the optimum scheduling of therapy.

92C50 Medical applications (general)
60K99 Special processes
Full Text: DOI
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