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A regularization procedure for estimating cell kinetic parameters from flow-cytometry data. (English) Zbl 0599.92010
The problem of estimating kinetic parameters such as the DNA synthesis rate and the S-phase influx in a cell population monitored by flow cytometry is considered. The population can be in any growth state, assuming that there is no cell loss. The growth curve of the population and a sequence of DNA-content histograms are required data.
Our approach, based on the use of continuity equations to model the population dynamics, utilizes a regularization procedure in order to filter the population-size data. Some properties of the procedure, together with an evaluation of its performance on simulated data, are presented.

92Cxx Physiological, cellular and medical topics
92D25 Population dynamics (general)
Full Text: DOI
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