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Pharmacokinetic models in enterohepatic circulation. (English) Zbl 0741.92008

Summary: Two extended one- and two-compartment models are proposed to explain the multiple-peak phenomena of drugs subject to enterohepatic circulation. The models are formed by adding a storage compartment on the basis of corresponding classic models. Suppose that the circulation will be repeated at regular intervals until the effective amount of drugs released to the absorption compartment can be neglected. The concentration time equations of bolus intravenous and oral administration undergoing \(n\) circulations are deduced to express the quantitative contribution of each circulation. Furthermore, the concept of total bioavailability is introduced to describe the bioavailability of drugs obeying the mechanism of enterohepatic circulation.

MSC:

92C45 Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.)
93C30 Control/observation systems governed by functional relations other than differential equations (such as hybrid and switching systems)
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