Choi, S. C.; Pepple, P. A. Monitoring clinical trials based on predictive probability of significance. (English) Zbl 0715.62236 Biometrics 45, No. 1, 317-323 (1989). Summary: At a given point in a clinical trial, investigators may ask the question: “What is the likelihood of a significant result if the trial were continued?” One possible answer to this question is to examine a predictive probability of the significant difference with further patient accrual. This paper proposes and investigates the approach in trials for comparing the means of two normal populations. Two methods for calculating the predictive probability are examined. The results indicate that the predictive probability can be a useful conservative measure in monitoring trials. Cited in 7 Documents MSC: 62P10 Applications of statistics to biology and medical sciences; meta analysis Keywords:curtailed procedure; interim analysis; clinical trial; predictive probability; comparing the means of two normal populations PDFBibTeX XMLCite \textit{S. C. Choi} and \textit{P. A. Pepple}, Biometrics 45, No. 1, 317--323 (1989; Zbl 0715.62236) Full Text: DOI